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“Also, in ovalbumin sensitized guinea pigs, AST-1 and diphenhydramine , a selective H1 antagonist, inhibited the cutaneous responses due to intradermal injection of histamine and ovalbumin.”
The West Indian medical journal • 2007 | View Paper
“Oral administration of S-1452 or intravenous administration of diphenhydramine significantly but incompletely reduced the increase in intranasal pressure following exposure of the nasal cavity of guinea pigs to aerosolized OA.”