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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Diphenhydramine
supplement:
Histidine
Research Papers that Mention the Interaction
“Simultaneous administration of diphenhydramine (20mg/kg, intraperitoneal) with l-histidine reduced the infarct size to 25% and 21% of that in the control group, respectively.”
Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains.“The effects of diphenhydramine were antagonized by histidine , the precursor of histamine.”
“The reduction in the late VEP components induced by pyrilamine and diphenhydramine was significantly antagonised by pre-treatment of histidine (200 and 500 mg/kg), but not by physostigmine even at a dose of 0.01 mg/kg.”
“Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine.”
“The increase in rCBF in the hippocampus induced by L-histidine was antagonized by both H1 and H2 antagonists ( diphenhydramine , pyrilamine and zolantidine).”
“4 The sedative effects induced by histidine after DOPA‐induced arousal in reserpine‐treated rabbits and mice were prevented by prior injection of the histamine Hrreceptor blockers, chlorpheniramine (2.5 mg/kg) or diphenhydramine (5 mg/kg).”
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