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Last Updated: 4 months ago

Possible Interaction: Diphenhydramine and Histidine

supplement:

Histidine

Research Papers that Mention the Interaction

Simultaneous administration of diphenhydramine (20mg/kg, intraperitoneal) with l-histidine reduced the infarct size to 25% and 21% of that in the control group, respectively.
Resuscitation  •  2011  |  View Paper
The effects of diphenhydramine were antagonized by histidine , the precursor of histamine.
The effects of diphenhydramine were antagonized by histidine , the precursor of histamine.
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences  •  2004  |  View Paper
The reduction in the late VEP components induced by pyrilamine and diphenhydramine was significantly antagonised by pre-treatment of histidine (200 and 500 mg/kg), but not by physostigmine even at a dose of 0.01 mg/kg.
Brain Research Bulletin  •  2003  |  View Paper
Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine.
Brain Research  •  2000  |  View Paper
The increase in rCBF in the hippocampus induced by L-histidine was antagonized by both H1 and H2 antagonists ( diphenhydramine , pyrilamine and zolantidine).
Methods and findings in experimental and clinical pharmacology  •  1999  |  View Paper