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Last Updated: 4 months ago

Possible Interaction: Diphenhydramine and Epinephrine

Research Papers that Mention the Interaction

Diphenhydramine with epinephrine was more painful to inject than were buffered lidocaine with epinephrine and lidocaine with epinephrine, and was less effective anesthetically than the other three solutions.
Diphenhydramine with epinephrine was significantly more painful to inject than was buffered lidocaine or buffered lidocaine with epinephrine, according to both the patients (p = 0.0003) and the physicians (p = 0.0037).
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine  •  1996  |  View Paper
We feel that the agressive administration of diphenhydramine in case 1 and diphenhydramine and epinephrine in case 2 controlled those reactions and allowed for continued administration of trimethoprim-sulfamethoxazole.
JAMA  •  1985  |  View Paper
At visit 1, an epinephrine rinse was strongly associated with decreasing LR compared with both diphenhydramine rinse and placebo (p < 0.001).
Allergy and asthma proceedings  •  2020  |  View Paper
Adequate doses of Benadryl augmented the pressor response to epinephrine.
The Journal of pharmacology and experimental therapeutics  •  1946  |  View Paper
Both epinephrine with diphenhydramine and heparin but not saline reversed shock.
Annals of emergency medicine  •  2006  |  View Paper
This relaxing action was not blocked by α- or β-blocking agents, atropine and diphenhydramine ; however, it could be antagonized with epinephrine , acetylcholine, and histamine.
Journal of pharmaceutical sciences  •  1973  |  View Paper
Diphenhydramine and surgical procedures, which suppressed MEA-induced increases in epinephrine , also tended to suppress blood glucose rises, and barbiturate anesthesia suppressed the blood glucose increases usually produced by MEA.
Archives internationales de pharmacodynamie et de therapie  •  1961  |  View Paper