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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Diphenhydramine
supplement:
Epinephrine
Research Papers that Mention the Interaction
“ Diphenhydramine with epinephrine was more painful to inject than were buffered lidocaine with epinephrine and lidocaine with epinephrine, and was less effective anesthetically than the other three solutions.”
“ Diphenhydramine with epinephrine was significantly more painful to inject than was buffered lidocaine or buffered lidocaine with epinephrine, according to both the patients (p = 0.0003) and the physicians (p = 0.0037).”
Comparison trial of four injectable anesthetics for laceration repair.“Conclusion Diphenhydramine was found to convert the vasodepressor effect of epinephrine and arterenol in the dog under adrenergic blockade with SY-28 to a vasopressor effect.”
“At visit 1, an epinephrine rinse was strongly associated with decreasing LR compared with both diphenhydramine rinse and placebo (p < 0.001).”
“The increases in serum glucose and epinephrine concentrations were reduced by pretreatment with diphenhydramine at 1mg/kg.”
Gatifloxacin-induced histamine release and hyperglycemia in rats.“Both epinephrine with diphenhydramine and heparin but not saline reversed shock.”
“Plasma adrenaline levels increased transiently 1 min after NT injection, and adrenalectomy and treatment with compound 48/80 or diphenhydramine markedly reduced the elevation of adrenaline levels after NT injection.”
“This relaxing action was not blocked by α- or β-blocking agents, atropine and diphenhydramine ; however, it could be antagonized with epinephrine , acetylcholine, and histamine.”
“ Diphenhydramine and surgical procedures, which suppressed MEA-induced increases in epinephrine , also tended to suppress blood glucose rises, and barbiturate anesthesia suppressed the blood glucose increases usually produced by MEA.”
“Adequate doses of Benadryl augmented the pressor response to epinephrine.”
The anti-histamine properties of benadryl, beta-di-methylaminoethyl benzhydryl ether hydrochloride.
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