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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Diosmin
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“Our study showed that especially high concentrations of diosmin decreased NO , PGE2, IL-6, IL-12, TNF-α production and mRNA levels of these mediators (p < 0.05).”
Diosmin suppresses the proinflammatory mediators in lipopolysaccharide-induced RAW264.7 macrophages via NF-κB and MAPKs signal pathways.“Additionally, both diosmin doses significantly reduced tissue levels of malondialdehyde and nitric oxide and increased those of glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, superoxide dismutase, and catalase, compared to the MTX-intoxicated group.”
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