Possible Interaction: Diosmin and Hesperidin

“In addition, feeding of diosmin and hesperidin , both alone and in combination, significantly inhibited the development of aberrant crypt foci.”

“These results indicate that diosmin and hesperidin , both alone and in combination, act as a chemopreventive agent against colon carcinogenesis, and such effects may be partly due to suppression of cell proliferation in the colonic crypts, although precise mechanisms should be clarified.”

“These findings suggest that the flavonoids diosmin and hesperidin , individually and in combination, are effective in inhibiting chemical carcinogenesis of the bladder, and that such inhibition might be partly related to suppression of cell proliferation.”

“These findings suggest that diosmin and hesperidin supplementation, individually or in combination, is effective in inhibiting the development of oesophageal cancer induced by MNAN when given during the initiation phase, and such inhibition might be related to suppression of increased cell proliferation caused by MNAN in the oesophageal mucosa.”

“Antihyperalgesic response of hesperidin , improved by a combination with diosmin (DS10/HS100) in both stimuli, was blockaded by haloperidol, bicuculline, and naloxone, but not WAY100635, antagonists.”