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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Diosmin
drug:
Fexofenadine
Research Papers that Mention the Interaction
“Therefore, we conclude that intake of DSN or dietary supplements containing DSN may potentially increase the absorption or bioavailability of FEX , a P-gp substrate in humans.”
“Treatment with SN significantly increased the peak maximum plasma concentration (Cmax) and area under the plasma concentration–time curve (AUC) of F EX by 49.2% (523.28 versus 780.63 ng/mL) and 64.4% (3459.48 versus 5687.74 ng h/mL), respectively as compared to control phase.”
The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers“CONCLUSIONS Di smin si gnificantly enhanced the oral bioavailability of fex ofenadine by the inhibition of P-gp mediated drug efflux during the intestinal absorption.”
“Co-administration of diosmin with fexofenadine can reduce the dosage and results in reduced side effects of fexofenadine.”
“Similarly effective permeability (Peff) of fexofenadine was increased significantly in ileum of diosmin pretreated group as compared with control.”
Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
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