Possible Interaction: Dinoprostone and Vitamin K

“Inhibition of PGE2 production by menatetrenone might be important in improving bone metabolism.”

“This study shows that menatetrenone inhibited PGE2 release from cells by inhibiting both PG production steps, AA release from the membrane and PG synthesizing activity with AA.”

“ Vitamin K2 had a synergistic effect with PGE2 on cancellous BV/TV as a result of the suppression of an increase in ES/BS observed by PGE2 treatment.”

“ Menatetrenone at greater than 3 x 10(-6) M significantly inhibited the calcium …) M of 1,25(OH)2D3 or 10(-7) M of prostaglandin E2 , and it also inhibited osteoclast-like multinucleated cell (MNC) formation induced by …-culture of spleen cells and stromal cells at the same concentrations.”

“ Menatetrenone (3 × 10−6‐3 × 10−5 M) inhibited the bone resorption induced by IL‐1α (2 U/ml), PGE2 (10−7 M), PTH (3 × 10−7 M), and 1,25‐(OH)2D3 (3 × 10−10 M) in a dose‐dependent manner.”

“ Menatetrenone also inhibited the PGE2 production stimulated by IL‐1α.”

“ Vitamin K1 (1-100 microM) inhibited the release of PGI2 and prostaglandin E2 (PGE2) by bovine aortic endothelial cells in culture, as measured by radioimmunoassay of 6-keto-prostaglandin F1 alpha (6-keto-PGE1 alpha) and PGE2.”

“In addition, vitamin K , in particularly MK-4 can suppress cyclooxygenase-2 expression and prostaglandin E2 production during osteoclast development, potentially contributing to the inhibition of bone resorption [4].”