Possible Interaction: Dinoprostone and Vitamin D

“Additionally, we showed that Vit D increased the expression of COX-2 and the synthesis of PGE2 in a time- and dose-dependent manner.”

“A link between vitamin D and PGE2 metabolism was shown recently.”

“ PGE2 response to vitamin D3 treatment was influenced by a participant's breast cancer risk.”

“Two thousand IU vitamin D3 lowered NAF PGE2 in normal-risk women (p=0.029), whereas 2,000 IU vitamin D3/celecoxib lowered NAF PGE2 in high-risk women (p=0.063).”

“ PGE2 decreased by39.2% in the group treated with vitamin D and increased by 16% in the placebo group.”

“A link between vitamin D and PGE2 metabolism was recently shown.”

“These findings suggest that vitamin D can regulate PGE2 synthesis and degradation and by this mechanism can modulate fibroblast-mediated tissue repair function.”

“ PGE2 decreased in the breast (p=0.01) only after receiving 2,000 IU vitamin D-3 ; 2,000 IU vitamin D-3 alone was more effective in decreasing PGE2 than 2,000 IU vitamin D-3 plus celecoxib (p=0.018).”

“… PGE2 resulted in a decrease in the rate of … CD49d expression), an increase in the synthesis of 24,25-dihydroxyvitamin D3 from substrate 25-hydroxyvitamin D3 (control 5.76 +/- 0.17, 72 h PGE2-treated … 3910 to 11285 receptors per cell in control and 7-day treated cells, respectively.”

“These results demonstrate that PGE2 specifically suppresses the effects of CT to stimulate synthesis of [3H]1,25-(OH)2D3 from [3H]25-hydroxyvitamin D3 and to inhibit tubular reabsorption of Pi without affecting urinary cAMP excretion.”

“In addition, both genistein and vitamin D inhibit the intraprostatic synthesis of prostaglandin E2 , an important mediator of inflammation.”