Possible Interaction: Dinoprostone and Tretinoin

“ All-trans retinoic acid (ATRA) increases the expression of COX-1 and COX-2 and the production of PGE2 , a prostaglandin with anti-inflammatory effects in human mesangial cells (MC).”

“…,ATRA … PGE2 production, but not in the same way as in human MC: (1) PGE2 production increased only slightly; (2) RAR and RXR were involved in … COX-2 upregulation, took more than 1 h. Therefore the regulation of COX by ATRA exhibits striking differences between human and rat MC.”

“Treatment with RA caused a dramatic increase in MBA‐15.6 cell responses to PTH and PGE2 but no significant effects could be observed in other clonal lines.”

“Using a human skin SCC line, it was shown that retinoid (9-cis-RA) could significantly suppress cell growth rate by inhibition of COX-2 expression and PGE2 biosynthesis.”

“ t-RA potently suppressed IL-1-induced expression of iNOS and COX-2 and production of nitric oxide and prostaglandin E2.”

“Preliminary results in human mesangial cells (MC) suggested that all‐trans retinoic acid (ATRA) increased the expression of COX‐2 and the production of prostaglandin E2 (PGE2), a PG with anti‐inflammatory effects in MC.”

“Both RA isomers caused the enhancement of PGE2 production and the up-regulation of COX-1 expression at the protein and mRNA levels.”

“Furthermore, RA blocked bile acid-induced COX-2 expression and prostaglandin E2 production only in the RAR-β positive cells.”

“In comparison with ATRA alone, the combination of PGE2 with ATRA caused an almost 20-fold decrease of effective concentration of ATRA.”

“Treatment with retinoids [all-trans-retinoic acid (all-trans-RA), 9-cis-RA, 13-cis-RA, and retinyl acetate] suppressed both basal levels of Cox-2 and EGF-mediated induction of Cox-2 protein and synthesis of prostaglandin E2.”

“ Retinoids [all-trans-retinoic acid (RA), 13-cis-RA, and retinyl acetate] markedly suppressed PMA-mediated increases in amounts of cyclooxygenase-2 (Cox-2) and the production of PGE2.”