Possible Interaction: Dinoprostone and Sphingosine 1-Phosphate

“ S1P significantly enhanced COX-2 expression and PGE2 secretion, and this was repressed by the selective COX-2 inhibitor celecoxib, the corticosteroid dexamethasone, or small interfering RNA (siRNA) knockdown of COX-2 expression.”

“In the present study, our results demonstrated that treatment with S1P significantly induced COX-2, but not COX-1, expression and increased PGE2 production in human granulosa cells.”

“Sphingosine‐1‐phosphate S1P ) has been shown to regulate cyclooxygenase‐2 (COX‐2)/prostaglandin E2 ( PGE2 ) expression and IL‐6 secretion in various respiratory diseases.”

“ S1P dose-dependently inhibited IL-1β-induced NF-κB p65, cyclooxygenase (COX)-2, MMP-1, MMP-3, MMP-13 and MMP-14 mRNA expression in human chondrocytes and IL-1β-induced PGE2 synthesis and GAG degradation in human cartilage explants.”

“ConclusionIt was suggested that the S1P-induced PGE2 was at least in part involved in the aggrecan-suppressing effect of S1P , seeing as COX inhibitors attenuated the effect.”

“ S1P alone significantly enhanced COX-2 expression and PGE2 production.”

“Analysis of the mechanisms involved in growth inhibition revealed that S1P rapidly increased prostaglandin E2 production and in turn cAMP, two growth inhibitory messengers for hMF; C2-ceramide and sphingosine, which inhibited hMF proliferation, did not affect cAMP levels.”

“We conclude that S1P inhibits proliferation of hMF, probably via an intracellular mechanism, through early COX-2-dependent release of prostaglandin E2 and cAMP, and delayed COX-2 induction.”

“ RsPP (2.5mg/kg) significantly inhibited the inflammatory peak of paw edema induced by histamine (44.0%), bradykinin (51.3%), or prostaglandin E2 (53.7%).”

“ S1P is able to cause increases in COX-2 and PGE2 levels in RAW cells.”