Possible Interaction: Dinoprostone and Secretin

“However, secretin induced a sevenfold increase in the PGE2 content of injured mucosa.”

“These results suggest that, in injured mucosa, PGE2 is involved in the healing process and in the action of secretin as well.”

“ PGE2 significantly decreased chymotrypsin concentration under Secretin.”

“ PGE2 significantly inhibited the secretin- and CCK-stimulated pancreatic secretion which was further suppressed by the concomitant ASA infusion.”

“ Secretin significantly increased concentrations of both somatostatin and prostaglandin E2.”

“ Secretin significantly increased the gastric mucosal content of prostaglandin E2 , and the increase was completely blocked by indomethacin.”

“Intravenous injection of 100 micrograms/kg PGE2 inhibited both the volume and amylase secretion of pancreatic juice stimulated with 1 U/kg.h of secretin.”

“Stimulation of secretion by bombesin, carbachol, VIP, and secretin was also inhibited by PGE2 , but not as pronounced as CCK-8-stimulated secretion.”

“Furthermore, 10 …/ml prostaglandin E2 had a small inhibitory effect on the amylase release induced by maximal stimulation of secretin (5 ×10−7 M), although the combination of prostaglandin E2 and secretin caused a bigger increase in the cellular cyclic AMP than that induced by each alone (additive effect).”

“On the other hand, prostaglandin E2 (10 μg/ml) induced an accumulation of the cellular cyclic AMP as observed by secretin (5 × 10−7M) but did not stimulate enzyme secretion.”

“It is concluded that PGE2 may have some centrally mediated effects on the protein pancreatic secretion , while the effects of enprostil appear mainly peripheral.”

“Intra-arterial injections of high doses of secretin (4 and 8 units) stimulated the output of both pancreatic secretin and PGE2 and 6-keto-PGF1 alpha into the blood of the pancreaticoduodenal vein dose-dependently.”