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Possible Interaction: Dinoprostone and Secretin



Research Papers that Mention the Interaction

However, secretin induced a sevenfold increase in the PGE2 content of injured mucosa.
These results suggest that, in injured mucosa, PGE2 is involved in the healing process and in the action of secretin as well.
Digestive diseases and sciences  •  1988  |  View Paper
PGE2 significantly decreased chymotrypsin concentration under Secretin.
Hepato-gastroenterology  •  1981  |  View Paper
PGE2 significantly inhibited the secretin- and CCK-stimulated pancreatic secretion which was further suppressed by the concomitant ASA infusion.
Pancreas  •  1995  |  View Paper
Secretin significantly increased concentrations of both somatostatin and prostaglandin E2.
Gastroenterology  •  1994  |  View Paper
Secretin significantly increased the gastric mucosal content of prostaglandin E2 , and the increase was completely blocked by indomethacin.
Digestion  •  1993  |  View Paper
Intravenous injection of 100 micrograms/kg PGE2 inhibited both the volume and amylase secretion of pancreatic juice stimulated with 1 U/kg.h of secretin.
Nihon geka hokan. Archiv fur japanische Chirurgie  •  1992  |  View Paper
Stimulation of secretion by bombesin, carbachol, VIP, and secretin was also inhibited by PGE2 , but not as pronounced as CCK-8-stimulated secretion.
The American journal of physiology  •  1991  |  View Paper
Furthermore, 10 …/ml prostaglandin E2 had a small inhibitory effect on the amylase release induced by maximal stimulation of secretin (5 ×10−7 M), although the combination of prostaglandin E2 and secretin caused a bigger increase in the cellular cyclic AMP than that induced by each alone (additive effect).
On the other hand, prostaglandin E2 (10 μg/ml) induced an accumulation of the cellular cyclic AMP as observed by secretin (5 × 10−7M) but did not stimulate enzyme secretion.
Pancreas  •  1990  |  View Paper
It is concluded that PGE2 may have some centrally mediated effects on the protein pancreatic secretion , while the effects of enprostil appear mainly peripheral.
Pancreas  •  1989  |  View Paper
Intra-arterial injections of high doses of secretin (4 and 8 units) stimulated the output of both pancreatic secretin and PGE2 and 6-keto-PGF1 alpha into the blood of the pancreaticoduodenal vein dose-dependently.
Archives internationales de pharmacodynamie et de therapie  •  1988  |  View Paper
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