Possible Interaction: Dinoprostone and Resveratrol

“PM extract, pterostilbene and resveratrol inhibited PGE2 production from LPS-stimulated human peripheral blood mononuclear cells (PBMC) with IC50 values of 3.2 +/- 1.3 microg/mL, 1.0 +/- 0.6 microM and 3.2 +/- 1.4 microM, respectively.”

“ Resveratrol and hydroxytyrosol decrease PGE2 levels.miR‐146a and Nrf2 are involved in the observed anti‐inflammatory effects.”

“… resveratrol … PGE2 but did not reduce iNOS, TNF&agr; or IL‐1&bgr; gene expression in LPS‐stimulated RAW 264.7 for 18 h. Resveratrol slightly … 6 h. Resveratrol and hydroxytyrosol 10 &mgr;M induced NRf2 nuclear translocation and reduced miR‐146a expression in LPS treated RAW 264.7.”

“Human platelets treated with resveratrol and stored for 5 d released less thromboxane B2 and prostaglandin E2 compared to control platelets.”

“ RSV (24 μM) also markedly depressed the levels of PGE2 and NO induced by IL-1β by 25% and 29% respectively ( P < 0.05).”

“In PBLs, RV decreased the secretion of PGE2 , CCL5/RANTES, and CXCL8/IL-8 but increased IL-1β, IL-6, and IL-10.”

“Our data showed that resveratrol , used in a concentration 20 times lower than 5-aminosalicylic acid, was able to significantly reduce NO and PGE2 production, iNOS and COX-2 expression and reactive oxidant species formation induced by the cytokine challenge.”

“Unlike genistein, resveratrol and related compounds dose-dependently reduced PGE2 production.”

“ Resveratrol reversed the elevation of leukotriene B4 (from 6.40 +/- 0.65 to 2.92 +/- 0.30 pmol.mg protein-1) and prostaglandin E2 (from 11.46 +/- 1.15 to 8.02 +/- 0.80 nmol.mg protein-1), induced by H2O2 challenge in K562 cells.”

“ Resveratrol , sirtinol, EX527 and AGK2 significantly reduced PGE2 production by up to 100% in microglia.”

“Similarly, resveratrol reduced the expression of LPS-induced pro-inflammatory agents such as iNOS (P < 0.05), COX-2 (P < 0.05), prostaglandin E2 (PGE2) (P < 0.05) and anandamide (AEA) (P < 0.05).”