Possible Interaction: Dinoprostone and Quercetin

“The contents of inflammatory mediators inclusive of TNF‐&agr;, IL‐1&bgr;, IL‐6, PGE2 , COX‐2 and iNOS were down‐regulated markedly by QU.”

“Finally, HPLC analysis clearly demonstrated that quercetin is a major active component with suppressing activity on the release of inflammatory mediators (NO and PGE2 ), and the enzyme activities of Src, Syk, and IRAK-1.”

“These results indicate that quercetin inhibits synovial fibroblasts proliferation and MMPs, COX-2, and PGE2 production, which involved joint destruction in rheumatoid arthritis (RA), and suggest that it might be a new therapeutic agent for management of RA.”

“ Quercetin at 1-100 microM caused concentration-dependent inhibition of LTB4 and PGE2 production.”

“ Quercetin and the synthetic COX-2 inhibitors (10 microM) suppressed PGE2 production by approximately 70% after 24 h exposure (P < 0.001).”

“HPLC analysis showed that quercetin , which inhibits PGE2 production, is an active component in Ac-ME.”

“Treatment with quercetin resulted in a significant decrease in prostaglandin E2 and cyclooxygenase-2 levels as well as inducible nitric oxide synthase-mediated nitric oxide production induced by lipopolysaccharide.”

“ Quercetin , galangin, apigenin, and naringenin markedly decreased PGE2 release and COX-2 expression in a concentration-dependent manner.”

“ PGE2 production stimulated by either cytokines was also reduced by quercetin at 20 and 40 mumol.”

“However, quercetin , the aglycone of quercitrin, increases the colonic fluid absorption only in the presence of secretagogue compounds, such as PGE2 and sodium picosulphate.”