Possible Interaction: Dinoprostone and Proline

“ PGE2 has been shown to increase the transcription of pro –IL-1β.”

“ PGE2 decreased the uptake of proline and aminoisobutyric acid (AIB) by quiescent fibroblasts in culture.”

“ PGE2 had the inverse effect, i.e. no influence in the former group but reduced incorporation of proline in the latter group of patients.”

“… PGE2 and NA were able to influence the incorporation of [3H] proline in such a way that the stimulatory effect of PGE2 was counteracted by reserpine in the luteal phase of the cycle, while NA-stimulated incorporation of [3H] proline was inhibited by PGE2 in the late follicular phase.”

“In the presence of cortisol, the stimulatory effects of PGE2 on medium IGF-I and incorporation of [3H] proline into collagenase-digestible protein were highly correlated (r = 0.95).”

“Previous studies have shown that prostaglandin E2 (PGE2) has both inhibitory and stimulatory effects on the incorporation of proline into collagenase-digestible protein (CDP) in cultured fetal rat calvaria.”

“ DMPG (10(-10) M) decreased the incorporation of labeled proline and the synthesis of labeled hydroxyproline in slices from fibrotic livers to the same extent, suggesting that DMPG did not affect the hydroxylation of proline per se.”

“ Prostaglandin E2 (10−6 to 10−4 M) inhibited incorporation of labeled proline into collagenase digestible protein, but not noncollagen protein, in calvaria of 21-day fetal rats cultured in a chemically defined medium for 24 hours.”