Possible Interaction: Dinoprostone and Progesterone

“The expression of PGE2 synthase was significantly suppressed in TGs 5 and 10, and both PGE2 and PGF2α levels were decreased in luteal homogenates, particularly from CL in TG 5.”

“ Progesterone acts synergistically with prostaglandin E2 immunosuppressive.”

“ PGE2 inhibited basal and human chorionic gonadotrophin (HCG)-stimulated progesterone production (P < 0.01) in late luteal phase corpora lutea.”

“The proportion of luteal cells that responded to PGE2 with an increase in [Ca2+]i was smaller (P < 0.05) in corpora lutea collected during the early luteal phase (12%) in comparison with those collected during the latter half of the luteal phase (63-66%).”

“Thus, the inhibitory effects of PGE2 on luteal progesterone production observed in the late luteal phase are associated with activation of elements of the phosphatidylinositol pathway.”

“Secretion of progesterone by day 7 or 13 bovine luteal cells was increased by hCG, PGE1 or PGE2 which was increased further when co-incubated with adenosine (p less than 0.05).”

“Luteinizing hormone (LH) (50 ng/ml), dibutyryl cyclic adenosine monophosphate (Bu2cAMP) (10(-3)M), and prostaglandin E2 (PGE2) (1 microgram/ml) significantly stimulated the production of progesterone in short-term (4-hour) cell suspensions of five early and middle luteal phase corpora lutea.”

“Similarly, in long-term (10-day) monolayer cultures of …, human chorionic gonadotropin (hCG) (50 ng/ml) and PGE2 stimulated, but none of the … altered, the production of progesterone significantly, except for an inhibitory effect of norepinephrine and carbachol in … beta-estradiol (10(-7)M) added to the culture medium.”

“ Progesterone levels decreased from admission to birth in patients who underwent successful labor induction with dinoprostone [vaginal and cesarean birth after induced labor: 23% (P < 0.001) and 18% (P < 0.025) decrease, respectively], but not in those whose induction failed (6.4% decrease, P > 0.05).”

“While a causal relationship between progesterone decrease and effective dinoprostone-induced labor cannot be established, it is tempting to propose that dinoprostone may contribute to progesterone withdrawal and favor labor induction in humans.”

“ PGE2 induced the expression of StAR and the production of progesterone in GLCs from women with endometriosis, and the expression of StAR and the production of progesterone were increased in GLCs from women with endometriosis.”

“FSH, (Bu)2cAMP and PGE2 increased progesterone secretion and the accumulation of the steroidogenic acute regulatory protein mRNA in these cells.”

“Production of PGE2 was increased slightly by oxytocin without progesterone, and significantly with progesterone.”

“In prelabor amnion cells, IL-1β also increased IL-8 and PGE2 synthesis and both COX-2 and IL-8 mRNA and promoter expression; however, progesterone significantly attenuated these effects on IL-8 and PGE2 synthesis and COX-2 expression.”