Possible Interaction: Dinoprostone and Potassium

“Gastric outputs of sodium and potassium in response to modified shamfeeding were reduced by PGE2.”

“In contrast PGE2 inhibits the contractions of circular muscle caused by acetylcholine or potassium. (”

“ PGE2 then reduces sodium absorption in the principal cells of the cortical collecting tubule and increases potassium secretion.”

“In this model of mucosal injury, pretreatment with prostaglandin E2 or isoproterenol significantly and dose dependently decreased luminal hydrogen loss, potassium gain , and DNA accumulation in both shocked and normotensive animals.”

“two-fold PGE2 injection (0.5 mg/kg) during water load decreased diuresis, glomerular filtration, excretion of potassium , titration acids, ammonium, and increased urine pH. Sodium excretion was detected only if ACE had been blocked.”

“ PGE2 also inhibited ductal sensitivity to 5-hydroxytryptamine, histamine, and potassium.”

“… PGE2 … potassium concentration, i.e. percent increases in RBF produced by PGE2 were 44.9 +/- 10.5% in the control period (plasma K+, 3.47 +/- 0.…+, 5.45 +/- 0.25 mEq/L) and 44.9 +/- 7.2% in the recovery period (plasma K+, 4.55 +/- 0.21 mEq/L).”

“The release of beta-EI stimulated by high potassium concentration was not enhanced by indomethacin, although this release was sensitive to inhibition by PGE2.”

“Stimulation with potassium (80 mM) induced an equally strong release of PGE2 and LHRH from the MEs of both fed and starved rats.”

“Increasing concentrations of PGE2 progressively increase response amplitudes to both noradrenaline and potassium but have no effect on baseline pressure.”

“PGF2 alpha, like PGE2 , enhances responses to both noradrenaline and potassium but, unlike PGE2, strongly elevates baseline pressure.”