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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprostone
supplement:
Phosphatidic Acid
Research Papers that Mention the Interaction
“In cells in which the phosphatidylcholine …-lyso-sn-glycero-3-phosphocholine, prostaglandin E2 … [3H]phosphatidic acid and its subsequent conversion to [3H]diradylglycerol, implying an effect at the level of phospholipase D. In … of [3H]phosphatidylcholine to generate [3H]phosphatidylethanol (a phospholipase D-dependent reaction) was also markedly inhibited.”
Cyclic AMP-elevating agents block chemoattractant activation of diradylglycerol generation by inhibiting phospholipase D activation.“Deleterious effects of PA are associated with the secretion of proinflammatory cytokines, such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and the production of nitric oxide, prostaglandin E2 , which are predominantly released by macrophage Raw264.7 cells.”
Phosphatidic Acid Regulates Systemic Inflammatory Responses by Modulating the Akt-Mammalian Target of Rapamycin-p70 S6 Kinase 1 Pathway*“LPA and PA inhibited the elevation of cAMP caused by cholera toxin, prostaglandin E2 , or forskolin, but not the rise induced by ATP.”
“As well, PGE2 inhibited the fMLP-induced decrease of [3H]arachidonic acid in phosphatidylcholine and phosphatidylinositol and the increase in PA very significantly.”
“ PGE2 also suppressed the enhanced incorporation of [32P]Pi into phosphatidic acid (PA) and phosphatidylinositol in a dose-dependent manner in fMLP-stimulated neutrophils.”
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