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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dinoprostone and Phosphatidic Acid

Research Papers that Mention the Interaction

In cells in which the phosphatidylcholine …-lyso-sn-glycero-3-phosphocholine, prostaglandin E2 … [3H]phosphatidic acid and its subsequent conversion to [3H]diradylglycerol, implying an effect at the level of phospholipase D. In … of [3H]phosphatidylcholine to generate [3H]phosphatidylethanol (a phospholipase D-dependent reaction) was also markedly inhibited.
The Journal of biological chemistry  •  1991  |  View Paper
Deleterious effects of PA are associated with the secretion of proinflammatory cytokines, such as tumor necrosis factor-α, interleukin-1β, interleukin-6, and the production of nitric oxide, prostaglandin E2 , which are predominantly released by macrophage Raw264.7 cells.
Journal of Biological Chemistry  •  2003  |  View Paper
LPA and PA inhibited the elevation of cAMP caused by cholera toxin, prostaglandin E2 , or forskolin, but not the rise induced by ATP.
The Journal of biological chemistry  •  1994  |  View Paper
As well, PGE2 inhibited the fMLP-induced decrease of [3H]arachidonic acid in phosphatidylcholine and phosphatidylinositol and the increase in PA very significantly.
PGE2 also suppressed the enhanced incorporation of [32P]Pi into phosphatidic acid (PA) and phosphatidylinositol in a dose-dependent manner in fMLP-stimulated neutrophils.
The Journal of biological chemistry  •  1986  |  View Paper