Possible Interaction: Dinoprostone and Oxytocin

“Compared to prostaglandin F2 … for augmentation with oxytocin in labour was … women induced with prostaglandin E2 pessary (OR 0.46; 95%CI 0.23 to 0.93), vaginal misoprostol (OR 0.34; 95%… to 0.63) and oral misoprostol (OR 0.42; 95%CI 0.22 to 0.78).”

“We found that the duration time of induction with dinoprostone is 2 hours in average less than the inducement with oxitocin (p > 0.05).”

“A shorter induction delivery interval in the group receiving amniotomy and oxytocin after PGE2 priming was observed.”

“It is concluded that prostaglandin E2 plus oxitocin provide better short-term outcomes than oxitocine treatment and gave more short periods of labor in patients with fetal death.”

“Uterine contractions became more frequent (P < .01) and were judged to be more intense (P < .02) and earlier when oxytocin was used immediately after PGE2 placement.”

“Conclusion Pre-induction intracervical deposition of 1 mg PGE2 gel decreased the amount of oxytocin required to induce progressive labor and decreased the cesarean rate in patients who had medical or obstetric indications for delivery before 41 completed weeks.”

“Results The maximum oxytocin dose required to establish progressive labor was significantly lower in the PGE2 group (10.06 ± 8.50 versus 13.35 ± 9.27 mU/minute, P = .014).”

“There was a significant reduction in the requirement for oxytocin augmentation in women treated with PGE2 : primigravidae, odds ratio (OR), 0.27 and 95% confidence interval (CI), 0.12-0.61; multiparae, OR, 0.19 and 95% CI, 0.08-0.45.”

“The number of women who required oxytocin for labor augmentation was negatively correlated to the dose of PGE2 (p < 0.05).”

“The use of PGE2 gel for cervical ripening contributed to the longer induction‐to‐vaginal delivery interval noted in the oxytocin group.”

“The induction to delivery time as well as the total oxytocin dose were significantly reduced in the PGE2 group (p < 0.001).”