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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Dinoprostone and Niacin



Research Papers that Mention the Interaction

Mice that alternated between a 1% niacin diet and a control diet had higher urinary prostaglandin E2 (PGE2) metabolite levels when on niacin (2.8-fold increase; 95% confidence interval, 1.8–3.9).
Nutrition and cancer  •  2011  |  View Paper
OBJECTIVE Niacin , activating G-protein coupled receptor (GPR) 109A, stimulates release of vasodilatory prostaglandins (PGs) such as PGE2 which can elicit niacin-associated flushing side effects.
European review for medical and pharmacological sciences  •  2015  |  View Paper
Nicotinic acid treatment increased ex vivo prostaglandin E2 , thromboxane B2 and leukotriene E4 synthesis to 185%, 165% and 175% of the initial values, respectively.
Pharmacology & toxicology  •  1999  |  View Paper
Results:It was shown that at non-cytotoxic concentrations, NA inhibits the production of a variety of pro-inflammatory agents, such as tumor necrosis factor α, interleukin 6, NO, PGE2 , and the generation of ROS.
Archivum Immunologiae et Therapiae Experimentalis  •  2008  |  View Paper
Although nicotinamide significantly did not reduce macroscopic damage, it decreased both MPO activity and PGE2 colonic levels.
European journal of pharmacology  •  2007  |  View Paper
PGE2 potentiated the CA release induced by stimulation of nicotinic or muscarinic cholinergic receptors and also by stimulation with excess K+ or caffeine.
European journal of pharmacology  •  1988  |  View Paper
Niacin induced both PGD2 and PGE2 generation in a dose-dependent manner.
Journal of inflammation research  •  2012  |  View Paper