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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprostone
supplement:
Niacin
Research Papers that Mention the Interaction
“Mice that alternated between a 1% niacin diet and a control diet had higher urinary prostaglandin E2 (PGE2) metabolite levels when on niacin (2.8-fold increase; 95% confidence interval, 1.8–3.9).”
High Dietary Niacin May Increase Prostaglandin Formation but Does Not Increase Tumor Formation in Apc Min/+ Mice“OBJECTIVE Niacin , activating G-protein coupled receptor (GPR) 109A, stimulates release of vasodilatory prostaglandins (PGs) such as PGE2 which can elicit niacin-associated flushing side effects.”
“ Nicotinic acid treatment increased ex vivo prostaglandin E2 , thromboxane B2 and leukotriene E4 synthesis to 185%, 165% and 175% of the initial values, respectively.”
“Results:It was shown that at non-cytotoxic concentrations, NA inhibits the production of a variety of pro-inflammatory agents, such as tumor necrosis factor α, interleukin 6, NO, PGE2 , and the generation of ROS.”
1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages“Although nicotinamide significantly did not reduce macroscopic damage, it decreased both MPO activity and PGE2 colonic levels.”
“ PGE2 potentiated the CA release induced by stimulation of nicotinic or muscarinic cholinergic receptors and also by stimulation with excess K+ or caffeine.”
“ Niacin induced both PGD2 and PGE2 generation in a dose-dependent manner.”
Attenuation of niacin-induced prostaglandin D2 generation by omega-3 fatty acids in THP-1 macrophages and Langerhans dendritic cells
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