Possible Interaction: Dinoprostone and Methionine

“The present studies show that prostaglandin E2 at 10-6 M decreased c-myc expression in these cells.”

“At low concentration (10−11 M) PGE2 increased DNA synthesis whereas at higher concentration ( 10−7 M ) it was inhibitory.”

“ Prostaglandin‐E2 in concentrations of 10‐6 and 10‐7 M markedly depressed monocyte‐mediated cytolysis.”

“ PGE2 inhibited the release of CA both in the presence and in the absence of K+, as well as in the presence of ouabain ( 10−3 M).”

“The suppressive effect of PGE2 decreased when its concentration was lowered and disappeared at 10−9 M PGE2 (this concentration corresponded to the basal level of non‐stimulated macrophage synthesis of PGE2).”

“It has been established that exposure of M luminal diameters to PGE2 desensitizes the suppressive function of PGE2.”

“When prostaglandin E2 (PGE2) was added to the lymphocyte culture at 10−7 M , anti‐TNP IgE response was augmented two‐ to fourfold.”

“In the sodium-replete dog, M did not affect mean arterial blood pressure (MABP), renal blood flow (RBF), glomerular filtration rate, (GFR), or urine volume (V), but reduced the urinary excretion of sodium (UNaV) by 47%, and of immunoreactive PGE2 (iPGE2) by 90%.”

“ PGE2 caused relaxation of contractions induced by either 25 mM KC1 or norepinephrine (10∼9 g/ ml), and these relaxations were inhibited by 10∼4 M ouabain.”

“However, while PGE2 caused a dose-dependent rise in pituitary cyclic AMP levels (from doubling at 10−7 M to a two-hundred fold increase at 10−5 M ), the ionophores had no effect on the concentrations of this nucleotide.”