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Last Updated: 4 months ago

Possible Interaction: Dinoprostone and Melatonin



Research Papers that Mention the Interaction

Stimulation of CYP19A1 PII-mRNA and aromatase activity by prostaglandin E2 (PGE2) were significantly attenuated by physiological doses of MLT.
Breast Cancer Research and Treatment  •  2012  |  View Paper
Pretreatment with melatonin (10 microM) blocked the effects of Pb on GSH content and caspase-3 activity, and showed significant improvement in reducing the level of PGE2.
International journal of toxicology  •  2006  |  View Paper
A previous study showed that exogenous melatonin is able to counteract the decrease in IL-2 production caused by prostaglandin E2 (PGE2) in human lymphocytes via its membrane receptor.
Journal of cellular physiology  •  2006  |  View Paper
However, exogenously given MLT significantly reduced the 3-NT formation as well as prostaglandin ( PGE2 ) levels in the brain.
Biological Trace Element Research  •  2018  |  View Paper
Melatonin treatment significantly decreased COX, PGE2 and caspase-3 activity, increased Bcl-2 and had no effect on NF-κB levels in experimental PD.
Neurochemistry International  •  2014  |  View Paper
This protective effect of melatonin was accompanied by a significant rise in the GBF and plasma melatonin and gastrin levels and in mucosal generation of PGE2.
Journal of pineal research  •  2005  |  View Paper
In this paper, we summarize the results of in vitro studies showing that physiological concentrations of melatonin inhibit the norepinephrine-induced activation of prostaglandin E2 (PGE2) and cyclic AMP production in rat medial basal hypothalamus (MBH).
Interestingly, a concentration of melatonin as low as 1 nM, which is roughly equivalent to the nocturnal serum physiological concentration of the hormone in the rat, significantly inhibit PGE2 and cyclic AMP production in the MBH.
Journal of pineal research  •  1998  |  View Paper
PE led to an impairment of lymphocyte proliferation and an increase of dinoprostone production, which were restored by ip Mel 10 at 16:00 for 7 d. Mel promoted lymphocyte proliferation and inhibited dinoprostone production in intact rats.
Zhongguo yao li xue bao = Acta pharmacologica Sinica  •  1995  |  View Paper
PGE2 was shown to play an essential role in the gonado-inhibiting effect of melatonin in Syrian hamsters by transforming the neuroendocrine signal to gonadal reactivity.
Journal of Neural Transmission / General Section JNT  •  1994  |  View Paper
Exposure of pineal and median eminence explants to nanomolar concentrations of PGE2 augments melatonin and GnRH release, respectively.
Neuroendocrinology  •  1983  |  View Paper
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