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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Dinoprostone
supplement:
Melatonin
Research Papers that Mention the Interaction
“ Melatonin markedly inhibited hydrogen peroxide (H2O2)‐stimulated cytotoxicity, iNOS, and COX‐2 protein and mRNA expression, as well as the downstream products, NO and PGE2.”
Cytoprotective and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway“Stimulation of CYP19A1 PII-mRNA and aromatase activity by prostaglandin E2 (PGE2) were significantly attenuated by physiological doses of MLT.”
“Pretreatment with melatonin (10 μM) blocked the effects of Pb on GSH content and caspase-3 activity, and showed significant improvement in reducing the level of PGE2.”
“A previous study showed that exogenous melatonin is able to counteract the decrease in IL‐2 production caused by prostaglandin E2 (PGE2) in human lymphocytes via its membrane receptor.”
“In this model, melatonin counteracts the effects of PGE2 on IL‐2 and cAMP production.”
“This suggests that modifying melatonin at either the N1-position or the N-acetyl side chain affected production of NO, PGE2 and IL-6 in in vitro model.”
Anti-Inflammatory Comparison of Melatonin and Its Bromobenzoylamide Derivatives in Lipopolysaccharide (LPS)-Induced RAW 264.7 Cells and Croton Oil-Induced Mice Ear Edema“However, exogenously given MLT significantly reduced the 3-NT formation as well as prostaglandin ( PGE2 ) levels in the brain.”
“ Melatonin treatment significantly decreased COX, PGE2 and caspase-3 activity, increased Bcl-2 and had no effect on NF-κB levels in experimental PD.”
“This protective effect of melatonin was accompanied by a significant rise in the GBF and plasma melatonin and gastrin levels and in mucosal generation of PGE2.”
“ PGE2 was shown to play an essential role in the gonado-inhibiting effect of melatonin in Syrian hamsters by transforming the neuroendocrine signal to gonadal reactivity.”
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