Possible Interaction: Dinoprostone and Masoprocol

“Using Swiss 3T3 cells, we found that PDGF-stimulated arachidonic acid mobilization and prostaglandin E2 production was abolished by NDGA in a dose-dependent manner.”

“…,NDGA produced a decrease in peroxidase secretion (peroxidase secreted: basal: 0.44 +/- …; NDGA 2.5 x 10(-6) M: 0.20 +/- 0.02; prostaglandins E2 (PGE2) 10(-7)M: 1.32 +/- 0.5; NDGA + PGE2: 0.46 +/- ….035), an effect that was exerted by the inhibition on prostaglandins synthesis.”

“ NDGA and 5, 6-dhAA inhibited the hyperalgesia associated with activation of … protein kinase A pathway, elicited by the direct-acting hyperalgesic agent prostaglandin E2 or by the catalytic subunit of protein kinase A. The hyperalgesia produced by active MAPK was not blocked by any of the lipoxygenase inhibitors.”

“The combination NDGA+L-NAME significantly reduced the uveitis intensity, MPO in the iris/ciliary body, and the levels of nitrites, LTB4, PGE2 , and PAF in aqueous humor.”

“Incubation of tumor‐bearer's macrophages in vitro with INDO (10‐6M and 10‐7M) or 10‐6M NDGA for 4 h reduced PGE2 release, but 10 ‐7M NDGA markedly enhanced the PGE2 release.”

“The lipoxygenase inhibitor NDGA also reduced the accumulation of PGE2 and PGF2 alpha.”

“Ovarian tissue levels of prostaglandins after 7 h of perfusion with LH + NDGA or with LH alone showed that, in five of the six ovaries perfused in this group, the tissue levels of PGE2 , 6-keto-PGF1 alpha and PGF2 alpha were higher in the presence of NDGA.”

“On the contrary, a combination of LTC4 (10 ng/h) and PGE2 (1 microgram/h) along with NDGA (5 micrograms/h) significantly increased the uterine weight to a level that was comparable to that induced by the infusion of the vehicle.”

“The infusion of LTC4 (10 ng/h) or PGE2 (1 microgram/h) with NDGA , at 1 and 5 micrograms/h, could not overcome its inhibitory effect on decidualization.”

“The intrauterine infusion of NDGA for 24 h inhibited the release of PGE2 , PGF2 alpha, LTC4 and LTB4 as compared to those released by the vehicle-infused horns.”

“Both production of PGE2 and LTC4 were suppressed by NDGA at 1 mg/ear which also inhibited ear swelling.”

“Blockers of arachidonic acid metabolism via cyclo-oxygenase (indomethacin and acetylsalicylic acid) or via lipoxygenase(s) nordihydroguaiaretic acid and dithizone) were able to reduce the positive inotropism of PGE2.”