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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Dinoprostone
supplement:
Manganese
Research Papers that Mention the Interaction
“Additionally, Mn increased interleukin1-β and prostaglandin E2 levels and altered caspase-3 and Bcl-2 expression.”
Neurotoxic Outcomes of Subchronic Manganese Chloride Exposure via Contaminated Water in Adult Male Rats and the Potential Benefits of Ebselen“Moreover, the authors report a doseand ime-dependent increase in brain prostaglandin E2 levels (used as biomarker of neuroinflammation) due to Mn , that is statistically ignificant only in the 8 dose Mn treated group vs. the control group Santos et al., 2012).”
“ Mn injections (days 1, 4 and 7) induced significant increases in F2-IsoPs and PGE2 in adult mouse brain 24 h following the last injection.”
“Treatment of neurons with 500 microM Mn also resulted in time-dependent increases in the levels of the inflammatory biomarker, prostaglandin E2 (PGE2).”
“ Manganese potentiated COX-2 expression and PGE2 generation by lipopolysaccharide/interferon-gamma-activated astrocytes.”
“Within non-toxic concentrations, manganese caused an elevation in the expression of cyclooxygenase-2 (COX-2) mRNA and protein and increased PGE2 release.”
“ Manganese as inhibitor of the A23187-induced calcium influx decreased PGE2 synthesis.”
“Ca2+-channel antagonists, such as nifedipine, verapamil, diltiazem and manganese inhibited PAF-induced arachidonate and PGE2 release in a dose-dependent manner.”
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