Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Dinoprostone and Linolenic Acid

Research Papers that Mention the Interaction

PGE2 , LTB4 synthesis and ALOX5 expression was suppressed by LA, GLA, ALA and DHA; whereas AA, EPA and 5-FU enhanced PGE2 but paradoxically AA decreased and EPA and 5-FU enhanced LTB4 synthesis in RKO cells.
PloS one  •  2015  |  View Paper
It was found that a combination of EPA + DCHA (6:4), DCHA and ALA caused significant reduction in synthesis of PGE2 (10.1-87.8%) and PGF2 alpha (14.0-54.6%) at the four dose levels studied.
Prostaglandins, leukotrienes, and essential fatty acids  •  1990  |  View Paper
Renal PGE2 is depressed by linolenic acid intake , while no effect is found for PGF2 alpha up to 8 energy% of linolenic acid supply.
Klinische Wochenschrift  •  1985  |  View Paper
Supplementation with ALA increased both PGE2 and PGF2α concentrations in the spent media (P ≤ 0.05).
Theriogenology  •  2014  |  View Paper
Exposure of LPS-stimulated cells to ALA inhibited the accumulation of nitrite and prostaglandin E2 (PGE2) in the culture medium.
Archives of pharmacal research  •  2007  |  View Paper