Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Dinoprostone and Linoleic Acid

Research Papers that Mention the Interaction

Tumor prostaglandin E2 concentrations were reduced by feeding the lower LA level; further dose-dependent decreases occurred in the DHA dietary groups and were accompanied by reduced levels of 12- and 15-hydroxyeicosatetraenoic acids.
Nutrition and cancer  •  1999  |  View Paper
The increased consumption of linoleic acid leads to higher levels of arachidonic acid and PGE2 as this fatty acid is their precursor.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology  •  1999  |  View Paper
Further, exposure to 100 to 500 μM LA increased prostaglandin E2 and leukotriene B₄ release.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology  •  2019  |  View Paper
The theory has been put forward that a diet high in linoleic acid and low in fat and riboflavin, such as the traditional diet in Transkei, results in overproduction of prostaglandin E2 in the gastric mucosa, and that this overproduction in turn causes a suppression of gastric acid production.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde  •  2003  |  View Paper
High intake of linoleic acid in a diet deficient in other polyunsaturated fatty acids and in riboflavin results in high tissue production of prostaglandin E2 , which in turn causes inhibition of the proliferation and cytokine production of Th1 cells, mediators of cellular immunity.
Postgraduate medical journal  •  1999  |  View Paper
Thus, our study suggests that an increase in the intake of linoleic acid from 4.8 to 7.6 en% decreases PGI2 and PGE2 synthesis by human endothelial cells, and supplementation of the diet with linoleic acid has a longer period of effectiveness than its decrease in the diet.
Journal of the American College of Nutrition  •  1991  |  View Paper
On the contrary, linoleic acid increased LPS-induced PGE2 production.
Veterinary Research Communications  •  2019  |  View Paper
Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that alters the synthesis of PGE2 and reduces the negative effects of TNF on body weight of healthy mice.
Research in nursing & health  •  2005  |  View Paper
Since a combination of linoleic acid (18:2 omega 6) and prostaglandin E2 or cAMP has synergistic effect on EGF-stimulated growth, it is suggested that additional cAMP-dependent protein kinase A (PK-A) independent pathways may also contribute to the linoleate effect on EGF action.
Prostaglandins, leukotrienes, and essential fatty acids  •  1993  |  View Paper
12-O-Tetradecanoylphorbol-13-acetate-induced epidermal prostaglandin E2 levels generally decreased with increasing dietary LA.
Cancer research  •  1992  |  View Paper
Show More