Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Dinoprostone and Kaempferol

supplement:

Kaempferol

Research Papers that Mention the Interaction

Luteolin dose-dependently inhibited the secretion … nitric oxide (NO) and prostaglandin E2 (PGE2) and diminished the levels of mRNA transcripts of inducible NO synthase (iNOS), tumor necrosis factor- (TNF-) α, and cyclooxygenase-2 (COX-2) in lipopolysaccharide- (LPS-) and pam3CSK-treated macrophage-like RAW264.7 cells without displaying cytotoxicity.
Mediators of inflammation  •  2015  |  View Paper
KF suppressed …) and prostaglandin E2 (PGE2), downregulated the cellular adhesion of U937 cells to fibronectin (FN), neutralized the generation of radicals, and diminished mRNA expression levels of … synthase (iNOS), TNF-α, and cyclooxygenase- (COX-) 2 in lipopolysaccharide- (LPS-) and sodium nitroprusside- (SNP-) treated RAW264.7 cells and peritoneal macrophages.
Mediators of inflammation  •  2015  |  View Paper
Among these, it was found that luteolin was able to strongly suppress NO and PGE2 production under the same conditions.
Journal of ethnopharmacology  •  2014  |  View Paper
Luteolin and kaempferol significantly reduced LPS-induced secretion of proinflammatory cytokines (IL-6 and IL-8) and prostaglandins ( PGE2 and PGF2α) in fetal membranes, IL-1β-induced COX-2 gene expression and prostaglandin production in myometrium, and IL-1β-induced MMP-9 activity in amnion and myometrial cells.
Oxidative medicine and cellular longevity  •  2013  |  View Paper
Kaempferol inhibited the proliferation of both unstimulated and IL-1β‑stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1β.
These results indicate that kaempferol inhibits synovial fibroblast proliferation, as well as the production of and MMPs, COX‑2 and PGE2 , which is involved in articular inflammation and destruction in rheumatoid arthritis (RA).
International journal of molecular medicine  •  2013  |  View Paper
Cyanidin and kaempferol at 1 microM reduced the level of PGE2 in LNCaP cell cultures and also attenuated the effect of arachidonic acid on increasing the amount of PGE2.
The Journal of nutritional biochemistry  •  2006  |  View Paper
At a concentration of 10(-4) M, kaempferol inhibited prostaglandin E2 production by 95%.
Kaempferol decreased the concentration of prostaglandin E2.
Nutrition  •  2005  |  View Paper
In this study, luteolin considerably reduced the IL-1β-induced production of NO, PGE2 , TNF-α, MMP-2, MMP-8 and MMP-9 and the expression of COX-2, iNOS, MMP-1, MMP-3 and MMP-13.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2019  |  View Paper
Liquid chromatography-tandem mass spectrometry analysis (LC-MS/MS) demonstrated that 1 g of ILE contains 27 mg of kaempferol, ….3 mg of vanillic acid, and 21 mg of combined amount of isoquercetin and hyperin, among which isoquercetin and kaempferol significantly suppressed IL-6, IL-1β, and PGE2 production.
Journal of medicinal food  •  2017  |  View Paper
Results Kaempferol treatment (up to 100 μM) in a concentration-dependent way caused reduction in the interleukin-1β-stimulated formations of PGE2 and NO.
Medical science monitor : international medical journal of experimental and clinical research  •  2017  |  View Paper
Show More