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Possible Interaction: Dinoprostone and Kaempferol

supplement:

Kaempferol

Research Papers that Mention the Interaction

Kaempferol inhibited the proliferation of both unstimulated and IL-1β‑stimulated RASFs, as well as the mRNA and protein expression of MMP-1, MMP-3, COX-2 and PGE2 induced by IL-1β.
These results indicate that kaempferol inhibits synovial fibroblast proliferation, as well as the production of and MMPs, COX‑2 and PGE2 , which is involved in articular inflammation and destruction in rheumatoid arthritis (RA).
International journal of molecular medicine  •  2013  |  View Paper
Cyanidin and kaempferol at 1 microM reduced the level of PGE2 in LNCaP cell cultures and also attenuated the effect of arachidonic acid on increasing the amount of PGE2.
The Journal of nutritional biochemistry  •  2006  |  View Paper
At a concentration of 10(-4) M, kaempferol inhibited prostaglandin E2 production by 95%.
Kaempferol decreased the concentration of prostaglandin E2.
Nutrition  •  2005  |  View Paper
In lipopolysaccharide (LPS)-activated RAW 264.7 cells, luteolin more potently inhibited the production of nitric oxide (NO) and prostaglandin E2 as well as the expression of their corresponding enzymes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) than luteolin-7-O-glucoside.
Nutrition research and practice  •  2013  |  View Paper
Luteolin dose-dependently inhibited the secretion … nitric oxide (NO) and prostaglandin E2 (PGE2) and diminished the levels of mRNA transcripts of inducible NO synthase (iNOS), tumor necrosis factor- (TNF-) α, and cyclooxygenase-2 (COX-2) in lipopolysaccharide- (LPS-) and pam3CSK-treated macrophage-like RAW264.7 cells without displaying cytotoxicity.
Mediators of inflammation  •  2015  |  View Paper
KF suppressed …) and prostaglandin E2 (PGE2), downregulated the cellular adhesion of U937 cells to fibronectin (FN), neutralized the generation of radicals, and diminished mRNA expression levels of … synthase (iNOS), TNF-α, and cyclooxygenase- (COX-) 2 in lipopolysaccharide- (LPS-) and sodium nitroprusside- (SNP-) treated RAW264.7 cells and peritoneal macrophages.
Mediators of inflammation  •  2015  |  View Paper
Among these, it was found that luteolin was able to strongly suppress NO and PGE2 production under the same conditions.
Among these, it was found that luteolin was able to strongly suppress NO and PGE2 production under the same conditions.
Journal of ethnopharmacology  •  2014  |  View Paper
In this study, luteolin considerably reduced the IL-1β-induced production of NO, PGE2 , TNF-α, MMP-2, MMP-8 and MMP-9 and the expression of COX-2, iNOS, MMP-1, MMP-3 and MMP-13.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2019  |  View Paper
Luteolin suppressed, in a dose-dependent manner, the clinical scores, number of inflammatory cells, the protein concentration, and the TNF-α, NO and PGE2 levels in the AqH and improved the histiologic status of the ocular tissue.
The Journal of veterinary medical science  •  2016  |  View Paper
We found that RES attenuated the LPS-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), monocyte chemotactic protein 1 (MCP-1) and IL-6.
International immunopharmacology  •  2016  |  View Paper
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