Possible Interaction: Dinoprostone and Hydroxytyrosol

“ HT significantly reduced oxidative (38.5-52.4% lipid peroxidation) and nitrosative stress (48.0-51.0% nitric oxide and 43.9-75.2% peroxynitrite concentration) and brain inflammatory mediators (18.6-40.6% prostaglandin E2 and 17.0-65.0% interleukin 1β concentration).”

“ Hydroxytyrosol … PGE2 but did not reduce iNOS, TNF&agr; or IL‐1&bgr; gene expression in LPS‐stimulated RAW 264.7 for 18 h. Resveratrol slightly … 6 h. Resveratrol and hydroxytyrosol 10 &mgr;M induced NRf2 nuclear translocation and reduced miR‐146a expression in LPS treated RAW 264.7.”

“Further study of the potential immune-modulating properties of HtyOle revealed a significant and concentration-dependent suppression of prostaglandin E2 production.”

“In a previous in vitro study, we showed that HT downregulated lipopolysaccharide-mediated expression of inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor alpha, and interleukin-1β, resulting in reduced nitric oxide and prostaglandin E2 production.”

“ HT suppressed NF-κB signaling and downregulated LPS-mediated expression of iNOS, cyclooxygenase-2, tumor necrosis factor alpha, and interleukin-1β at 12.5 µg/ml, resulting in reduced production of NO and prostaglandin E2.”

“The increase in prostaglandin E2 and interleukin 1β after reoxygenation were inhibited after incubation of brain slices with HT and after oral administration.”