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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Dinoprostone and Hydroxytyrosol

Research Papers that Mention the Interaction

Hydroxytyrosol also considerably reduced the expression of COX2 at both the mRNA and protein level (P<.05) and caused a clear dose-dependent reduction of PGE2 released into the culture medium (45% and 71% at 50 and 100 μM, respectively, P<.05).
The Journal of nutritional biochemistry  •  2013  |  View Paper
HT significantly reduced oxidative (38.5-52.4% lipid peroxidation) and nitrosative stress (48.0-51.0% nitric oxide and 43.9-75.2% peroxynitrite concentration) and brain inflammatory mediators (18.6-40.6% prostaglandin E2 and 17.0-65.0% interleukin 1β concentration).
Journal of agricultural and food chemistry  •  2017  |  View Paper
Hydroxytyrosol and resveratrol inhibited the production of NO and PGE2 but did not reduce iNOS, TNFα or IL-1β gene expression in LPS-stimulated RAW 264.7 for 18h.
International immunopharmacology  •  2017  |  View Paper
HT suppressed NF-κB signaling and downregulated LPS-mediated expression of iNOS, cyclooxygenase-2, tumor necrosis factor alpha, and interleukin-1β at 12.5 µg/ml, resulting in reduced production of NO and prostaglandin E2.
The Journal of veterinary medical science  •  2018  |  View Paper
The increase in prostaglandin E2 and interleukin 1β after reoxygenation were inhibited after incubation of brain slices with HT and after oral administration.
The Journal of nutritional biochemistry  •  2013  |  View Paper