Possible Interaction: Dinoprostone and Glutathione

“Introduction of GSH ester to buffer against oxidative stress was able to block the elevation of PGE2.”

“Reduced glutathione GSH ) acted to increase the biosynthesis of PGE2 at the expense of other PGs both in the presence and absence of various cytosols.”

“Hartl D, Starosta V, Maier K, Beck-Speier I, Rebhan C, Becker BF, Latzin P, Fischer R, Ratjen F, Huber RM, et al. Inhaled glutathione decreases PGE2 and increases lymphocytes in cystic fibrosis lungs.”

“Inhalation of GSH decreased BALF levels of PGE2 and increased CD4+ and CD8+ lymphocytes in BALF significantly but had no effect on markers of oxidative stress.”

“We conclude that GSH inhalation in CF patients increases lymphocytes and suppresses PGE2 in the bronchoalveolar space.”

“Addition of glutathione (GSH), a coenzyme of PGE2-isomerase, increased PGE2 production 2 to 5-fold during stimulation with anti-IgE. These data support the idea that arachidonic acid metabolites play an important role in modulating the “releasability” of human basophils.”

“Addition of glutathione or bicarbonate further increased the production of PGE2.”

“We found that PGE2 reduced intracellular reactive oxygen species levels, and simultaneously increased glutathione concentration and stimulated antioxidant gene expression in the oocyte.”

“ GSH increased GSH concentration and activities of catalase, glutathione peroxidase and superoxide dismutase in colonic mucosa, and decreased cyclooxygenase-2, prostaglandin E2 and thromboxane B2 levels.”

“Further, glutathione (GSH) is antagonistic to PGE2 synthesis.”

“The enhanced NK activity seen with oral GLN supplementation in the tumor-bearing host is associated with GSH mediated suppression of PGE2 synthesis.”

“The increase in protection offered by a combination of PGE2 with Cys, glucan, GSH , or 5-HT is less marked and the effect obtained is only additive.”