Possible Interaction: Dinoprostone and Glucosamine

“In MCF‐7 breast cancer cells, glucosamine effectively suppresses the PKC induction of COX‐2 and IL‐8 promoter activity, mRNA and protein levels, as well as the production of prostaglandin E2 (PGE2) and IL‐8.”

“Furthermore, the effect of glucosamine on the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and the binding of [125I] IL-1β to its …:Glucosamine significantly suppressed the IL-1β-induced IL-8 production as well as its mRNA expression (p < 0.05) at 1 mM. Furthermore, glucosamine (… PGE2 …).”

“Application of PGE2 to cultures treated with cycloheximide alone, or to cultures treated with cycloheximide plus xyloside, increased tritiated glucosamine incorporation into chondroitin, dermatan sulfate, and to a lesser extent into heparan sulfate.”

“Exposure of cells to PGE2 resulted in dose-dependent increases in glucosamine incorporation into all sulfated glycosaminoglycan subtypes.”

“In membranes from vaginally delivered women both oxytocin and PGE2 stimulated the incorporation of [3H]glucosamine , whereas oxytocin diminished radiolabelling in the other experimental groups.”

“From the 12th week of gestation until term pregnancy conditions were reversed, i.e. the incorporation of 3H proline was reduced and that of 3H glucosamine was augmented following treatment with PGE2.”

“ Glucosamine at 0.1 and 5 microg/mL significantly decreased IL-1-stimulated production of mPGEs and PGE2 , respectively, compared with that of positive control synoviocytes.”

“Furthermore, glucosamine reduced the production of nitric oxide and prostaglandin E2 in plasma (p < 0.05).Conclusions: These observations suggest that glucosamine is able to suppress the progression of adjuvant arthritis in rats.”

“At 25 mg/ml glucosamine also prevented IL-1beta-induced increases in nitric oxide production, prostaglandin E2 and proteoglycan release to media.”