Possible Interaction: Dinoprostone and Genistein

“NAC alone ameliorated IND-induced apoptosis, whereas GEN only significantly increased prostaglandin E2 level.”

“This study demonstrated that genistein , a selective tyrosine kinase inhibitor, blocked PGE2 production in human A431 and WISH cells and murine 3T3 cells in response to epidermal growth factor and platelet-derived growth factor.”

“We show that PGE2 enhances IL‐8 synthesis via the EP3 receptor and that genistein is able to down‐regulate the latter, as well as to decrease IL‐8 mRNA and protein expression, thereby inhibiting oral, uveal and cutaneous melanoma cell proliferation.”

“As a result genistein significantly reduced the secretion of PGE2 by these cells.”

“ Genistein significantly inhibited the stimulatory effect of spontaneous labour amniotic fluid on PGE2 and PGEM production by amnion and chorion respectively.”

“We further show that the tyrosine kinase inhibitors genistein and herbimycin A prevent IL-1 beta plus IFN-gamma-induced expression of COX-2 and iNOS and the production of PGE2 and nitric oxide by human islets.”

“In contrast to the nitrite production activin A induced PGE2 synthesis was susceptible to tyrosine kinase inhibition by genistein and tyrphostin 46 (IC50 was 10 and 20 μM, respectively).”

“ Genistein , an inhibitor of protein tyrosine kinases, also blocked long-term prostaglandin E2 formation.”

“The dose dependent effect of genistein on inhibition of mRNA for COX II correlated with the inhibition of the release of PGE2 into the media.”

“ Genistein , a known inhibitor of EGF receptor tyrosine kinase, changed neither the EGF effect on AA release nor its potentiation by oxysterol, whereas it inhibited PGE2 synthesis in both situations.”