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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dinoprostone and Gamma-Linolenic Acid

Research Papers that Mention the Interaction

Significant reductions in prostaglandin E2 , leukotriene B4, and leukotriene C4 produced by stimulated monocytes were seen after 12 weeks of GLA supplementation.
Arthritis and rheumatism  •  1990  |  View Paper
PGE2 , LTB4 synthesis and ALOX5 expression was suppressed by LA, GLA , ALA and DHA; whereas AA, EPA and 5-FU enhanced PGE2 but paradoxically AA decreased and EPA and 5-FU enhanced LTB4 synthesis in RKO cells.
PloS one  •  2015  |  View Paper
Gammalinolenic acid suppresses inflammation by acting as a competitive inhibitor of prostaglandin E2 and leukotrienes (LTs) and by reducing the auto-induction of interleukin1alpha (IL-1alpha)-induced pro-IL-1beta gene expression.
Seminars in arthritis and rheumatism  •  2005  |  View Paper
Both GLA and EPA caused a marked decrease in the synthesis of prostaglandins E2 and F2 alpha (P < 0.001) but under the experimental conditions used, there was no consistent effect on arachidonic acid uptake.
Prostaglandins, leukotrienes, and essential fatty acids  •  1994  |  View Paper