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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprostone
supplement:
Fish Oils
Research Papers that Mention the Interaction
“Following 3 months of fish oil, PGE2 decreased to 4.1 (1) and 9.6 (2.4) ng/ml in control and irradiated skin, respectively, p < 0.05.”
Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption.“In correlation with COXs down-regulation, fish oil significantly reduced the concentrations of PGE2 in ovaries.”
“Furthermore, lycopene and fish oil inhibited tumor progression through suppression of MMP-7, MMP-9, COX-2 and PGE2.”
“ConclusionThis study demonstrated the new mechanism behind the positive effects of dietary fish oils in inhibiting inflammation originates …, which can directly inhibit the inflammatory EP1-mediated PGE2 receptor signaling, and that the inflammatory response stimulated by PGE2 in the fat stromal cells, …, could be down regulated by fish oil ….”
“The different dietary oils and unsaturated fatty acids were used to affect cell signaling under the specific stimulation of a pathological amount of inflammatory PGE2.ResultsIt was identified that fish oil best inhibited the PGE2 signaling in the primary cultured stromal cells.”
“Hence, fish oil decreases production of prostaglandins like PGE2 and of leukotrienes like LTB4.”
“ PGE2 production decreases 50% when fish oil consumption produces tissue EPA/AA ratios of ≥0.2.”
“As PUFAs are precursors of prostaglandins and leucotriens, which are involved in phlogosis and immune response, a diet rich in fish oil reduces the production of PGE2 involved in many phlogosis events.”
“In conclusion, dietary supplementation of FO decreased the endometrial production of PGF2α and PGE2 by downregulating the COX-2, cPLA2 and PGFS transcripts in the doe.”
Effect of dietary n-3 polyunsaturated fatty acid rich fish oil on the endometrial prostaglandin production in the doe (Capra hircus).“Moreover, fish oil reduced the plasma tumor necrosis factor (TNF) α, muscle TNFα, and prostaglandin E2 concentrations, and muscle TNFα and cyclooxygenase 2 (COX2) mRNA abundance.”
“…,fish oil suppressed increases in the mRNA and protein levels of macrophage colony‑stimulating factor (M‑CSF), PU.1, microphthalmia-associated transcription factor (MITF), receptor … activation of NFκB (RANK) and RANK ligand (RANKL) and serum levels of tumor necrosis factor α (TNFα), interleukin‑6 (IL-6) and prostaglandin E2 (…).”
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