Possible Interaction: Dinoprostone and Epinephrine

“The fact that this stimulation is not inhibited by a β‐blocker (propranolol) and that the stimulation by prostaglandin E2 and adrenaline is additive indicates that each drug acts independently on the epidermal adenyl cyclase system.”

“The data support a pathway in which epinephrine induces the production of PGE2 which binds to EP1 receptors and activates PKC and NF-κB leading to NO synthesis.”

“In addition, an inhibitory effect, similar to that of epinephrine’s , was observed upon incubation with PGE2.”

“It was concluded that epinephrine inhibits the Na+/K+-ATPase by the sequential activation of α2 adrenergic receptors, Src, p38MAPK, and ERK leading to PGE2 release.”

“ Epinephrine seemed to affect a lesser increase in PGE2 and a greater increase in cAMP values in gingival tissues when compared with control samples.”

“ Epinephrine induced increased production of PGE2 both by control (3·5‐fold) and TB rats (27 per cent) KC, an effect blocked by propranolol.”

“Experiments conducted on male rats with congenital high and low resistance … hypoxia (HH and LH, respectively) have revealed, that injection of prostaglandin E2 (PHE2) 15 min … the injection of adrenalin essentially decreases the activity of lipid peroxidation in myocardium as … with animals which have been injected to only adrenalin.”

“In experiments on male rats it was established, that injection of prostaglandin E2 (PGE2) before the injection of adrenaline decrease essentially the activity of peroxidation of lipids in myocardium in comparison with animals which had only injection of adrenaline.”

“ Epinephrine stimulated PGE2, PGF2 alpha, and TXB2 synthesis at 22 degrees C but only stimulated PGE2 production at 5 degrees C. In tissues from CA frogs, epinephrine did not stimulate prostaglandin synthesis at either incubation temperature.”

“Prostaglandin E2 (PGE2) and 16,16-dimethyl PGE2 were found to inhibit a hepatic glycogenolysis stimulated by epinephrine in the presence of propranolol (alpha 1-adrenergic response), isoproterenol (beta-adrenergic response) and glucagon in primary cultures of rat hepatocytes.”

“When the cells were cultured in the presence of 2% newborn bovine serum, 1 microM epinephrine markedly stimulated PGE2 synthesis from endogenous arachidonic acid.”