Possible Interaction: Dinoprostone and Epigallocatechin Gallate

“We found that EGCG significantly inhibited PGE2 and EP1-selective agonist induced migration of HCC cells and increased the ratio of Bax/Bcl-2 even in the presence of ONO-DI-004 or PGE2.”

“Here, we showed that EGCG inhibits COX‐2 mRNA/protein expression or prostaglandin E2 (PGE2) production via up‐regulating microRNA hsa‐miR‐199a‐3p expression in interleukin (IL)‐1β‐stimulated human OA chondrocytes.”

“Conclusion:These findings suggest that the anti-HCC effects of EGCG might be mediated, at least partially, through the suppressing EP1 receptor expression and PGE2 production.”

“ EGCG (100 μg/mL) significantly inhibited the viability and migration of HepG2 cells induced by PGE2 or ONO-DI-004.”

“ EGCG may inhibit the expression of inflammatory mediators, such as COX-2, PGE2 , and IL-8, induced by IL-1β in human synovial fibroblasts.”

“HBP and EGCg significantly inhibited PGE2 production, whereas ACT did not.”

“ EGCG also caused a decrease in production of PGE2 , a major product of COX-2.”

“Treatment of TNF-α-stimulated HT29 cells with EGCG dose-dependently inhibited the synthesis of IL-8, MIP-3α, and PGE2.”

“Additionally, EGCG reduced spinal astrocytes and microglia activation, cytokines overexpression and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) pathway, downregulating inducible nitric oxide synthase (iNOS) activation, cyclooxygenase 2 (COX-2) expression, and prostaglandin E2 (PGE2) levels.”

“Dietary 0.5% EGCG also increased serum levels of leukotriene B4 and prostaglandin E2.”

“On the other hand, EGCG slightly decreased the elevated PGE2 production, however, this effect of EGCG was offset by hot water.”