Possible Interaction: Dinoprostone and Calcium Supplement

“These results suggest that renal PGE2 synthesis is stimulated or decreased by 1-week Ca loading or deprivation, indicating a possible antihypertensive role of renal PGE2 during high-Ca intake in hypertensives.”

“Specifically, Ca2+ incubation stimulated COX-2 and PGE2 synthase activity, microsomal PGE synthase 1 and the synthesis of PGE2 by activating the transcriptional activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) in n2a cells.”

“ PGE2 probably acts through its second messenger, cyclic adenosine 3'5'-monophosphate, which can antagonize Ca2+i signaling in T cells.”

“Both prostaglandin E2 and the catecholamines decrease the size of a rapidly exchangeable calcium pool , and prostaglandin E1 increases it.”

“Elevated levels of PGE(2 ) inhibit myogenic differentiation by decreasing the intracellular levels of calcium.”

“Neuroblastoma cells produced PGE2 and stimulation of serum-starved neuroblastoma cells with PGE2 increased the intracellular concentration of calcium and cyclic AMP with subsequent phosphorylation of Akt.”

“Total PGE2 content in the media of cultures grown on the three roughest surfaces (FA, CA , and TPS) was significantly increased 1.5-4.0 times over that found in media of cultures grown on plastic or smooth surfaces.”

“When PGE2 production was expressed per cell number, CA and TPS cultures exhibited six- to eightfold increases compared to cultures on plastic and smooth surfaces.”

“Removal of extracellular calcium reduced release of prostaglandin E2 to background levels, and inclusion of an inhibitor of protein synthesis abolished the second phase of release but not the first phase.”

“The results suggest that renal prostaglandin E2 may participate in calcium stone formation by regulating the renal tubular handling of calcium.”

“ Ca++ can stimulate prostaglandin E2 (PGE2) and/or prostacyclin (PGI2) release in vitro, which may modulate Ca++ vascular effects.”