Possible Interaction: Dinoprostone and Apigenin

“Intriguingly, Apg profoundly induced cyclooxygenase 2 (COX2) and prostaglandin E2 (PGE2) gene expression in response to IL-1β treatment.”

“ Apigenin suppressed tumor necrosis factor α-induced cell proliferation and prostaglandin E2 expression via the attenuation of nuclear factor κB pathway in endometriotic stromal cells in vitro.”

“ Apigenin significantly inhibited the nicotine- and LPS-induced production of NO, PGE2 , IL-1beta, TNF-alpha, IL-6, and IL-12, and the upregulation of iNOS and COX-2 in hPDL cells.”

“ Apigenin and PD 98509 significantly inhibited both EGF and IL‐1β stimulated 3H‐AA and PGE2 release and cell proliferation whereas, SB 203580 had no significant effect on EGF or IL‐1β stimulated 3H‐AA release, or cell proliferation but significantly suppressed EGF or IL‐1β stimulated PGE2 release.”

“Analysis of the non-tumor epidermis revealed that apigenin reduced COX-2, PGE2 , EP1, and EP2 synthesis and also increased terminal differentiation.”

“Quercetin, galangin, apigenin , and naringenin markedly decreased PGE2 release and COX-2 expression in a concentration-dependent manner.”

“A similar, though less active, mode of action was found with quercitrin, while apigenin and luteolin reduced leucocyte accumulation and PGE2 formation, but not LTB4–formation.”

“It is concluded that apigenin possesses potent analgesic, anti-inflammatory, and antiproliferative activities, which might be due to the inhibition of PGE2 as well as proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor- α.”