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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprostone
supplement:
Alpha-Tocopherol Succinate
Research Papers that Mention the Interaction
“Administration of alphaTOS may block inflammatory responses mediated by PGE2 , thereby inhibiting the initiation and progression of lung cancer.”
“These results suggest that alphaTOS inhibits COX activity, thereby inhibiting PGE2 production in human lung epithelial cells, despite the lack of antioxidant activity.”
“alphaTOS had no effect on PMA-induced AA release or COX-2 expression, although post-incubation with alphaTOS inhibited COX activity and prostaglandin ( PGE2 and PGF(2alpha)) production in PMA-stimulated cells.”
Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells.“Previous studies have shown that prostaglandin E2 (PGE2) and vitamin E succinate can act in an additive manner to inhibit the proliferation of human oral squamous carcinoma cells (SCC-25).”
“ Prostaglandin E2 and vitamin E succinate , individually at 10(-9)-10(-6) M, caused significant dose-dependent inhibition in DNA synthesis.”
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