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Possible Interaction: Dinoprostone and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

ACTH and cortisol responses to CRH were greater during PGE2 infusion compared to the control study.
The results indicate that PGE2 positively modulates CRH-induced ACTH secretion.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  1992  |  View Paper
Animal experiments show that PGE2 affects the release of ACTH and corticosteroids.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  1987  |  View Paper
Prostaglandin E2 inhibits release of beta-endorphin and corticotropin from pituitary corticotroph cells, suggesting that suppression of prostaglandin levels should increase beta-endorphin release.
Clinical pharmacology and therapeutics  •  1997  |  View Paper
Local application of prostaglandin E2 (PGE2) to this region elicits increases in core body temperature, heart rate, and plasma levels of adrenocorticotrophic hormone (ACTH).
Neuroscience Letters  •  2006  |  View Paper
PGE2 (100 ng) produced marked increases in blood pressure, heart rate, and plasma ACTH concentration.
Brain Research  •  2000  |  View Paper
Exogenous … of PGE2 is associated with robust increases in the circulating concentrations of ACTH and cortisol and it has therefore been proposed that endogenous PGE2 modulates the activity of the fetal HPA axis, which is the primary determinant of parturition and essential for the maturation of vital organ systems.
Journal of neuroendocrinology  •  1996  |  View Paper
Intravenous bolus injection of PGE2 at doses of 0.1 mg and 1.0 mg/kg BW resulted in dose-dependent significant elevations of the plasma ACTH with peak levels being 155 +/- 27 pg/ml (at 10 min) and 343 +/- 35 pg/ml (at 20 min), respectively.
Neuroendocrinology  •  1995  |  View Paper
ICV administered PGE2 also stimulated the activity of the hypothalamic-pituitary-adrenal axis, as reflected by increased plasma concentrations of adrenocorticotropic hormone and corticosterone.
The American journal of physiology  •  1995  |  View Paper
PGE2 (1000 nmol/l) significantly (P less than 0.05) enhanced the ability of AVP, but not CRF, to stimulate ACTH secretion.
The Journal of endocrinology  •  1992  |  View Paper
infusion of PGE2 (30 micrograms.h-1) also stimulated ACTH secretion although the peak response was delayed and considerably less compared with the same dose administered intravenously.
infusion of prostaglandin E2 (30 or 120 micrograms.h-1) caused a significant dose-related increase in fetal plasma concentrations of ACTH.
Journal of developmental physiology  •  1992  |  View Paper
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