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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprostone
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Prostaglandin E2 inhibits release of β‐endorphin and corticotropin from pituitary corticotroph cells, suggesting that suppression of prostaglandin levels should increase β‐endorphin release.”
Ibuprofen elevates immunoreactive β‐endorphin levels in humans during surgical stress“ ACTH and cortisol responses to CRH were greater during PGE2 infusion compared to the control study.”
“The results indicate that PGE2 positively modulates CRH-induced ACTH secretion.”
“Animal experiments show that PGE2 affects the release of ACTH and corticosteroids.”
“Local application of prostaglandin E2 (PGE2) to this region elicits increases in core body temperature, heart rate, and plasma levels of adrenocorticotrophic hormone (ACTH).”
Microinjection of prostaglandin E2 and muscimol into the preoptic area in conscious rats: Comparison of effects on plasma adrenocorticotrophic hormone (ACTH), body temperature, locomotor activity, and cardiovascular function“The present results show that ACTH responses induced by intravenous injection of IL-1α were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH.”
“The inhibition of glucose transport induced by lipolytic hormones such as glucagon, catecholamines or ACTH in the presence of adenosine deaminase was antagonized by PGE2.”
“ PGE2 (100 ng) produced marked increases in blood pressure, heart rate, and plasma ACTH concentration.”
“Exogenous … of PGE2 is associated with robust increases in the circulating concentrations of ACTH and cortisol and it has therefore been proposed that endogenous PGE2 modulates the activity of the fetal HPA axis, which is the primary determinant of parturition and essential for the maturation of vital organ systems.”
“ICV administered PGE2 also stimulated the activity of the hypothalamic-pituitary-adrenal axis, as reflected by increased plasma concentrations of adrenocorticotropic hormone and corticosterone.”
“ PGE2 (1000 nmol/l) significantly (P less than 0.05) enhanced the ability of AVP, but not CRF, to stimulate ACTH secretion.”
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