Possible Interaction: Dinoprost and Vitamin E

“Luteal tissues obtained at 24 h after PGF2 alpha revealed that internucleosomal DNA fragmentation and cellular collapse were inhibited by alpha-tocopherol.”

“The registered dietary intakes of ascorbic acid and α-tocopherol were negatively associated linearly and in quartiles with both PGF2α , hsCRP, IL-6 and F2-isoprostanes, where ascorbic acid intake generally was more strongly associated.”

“… vitamin E prolonged mean LDL oxidation lag time but, paradoxically, further …-isoprostanes to 188.2±10.9 nmol/L and PGF2&agr ; to 7.8±0.4 nmol/L. These data suggest that vitamin E may … as a pro-oxidant in cigarette smokers consuming a high polyunsaturated fat diet.”

“Boars at 18 mo of age had lower PGF2alpha concentrations in the prostate (P < .05) and seminal vesicles (P < .01) when vitamin E was fed, whereas Se had no effect.”

“ Hepatic PGF2 alpha status was correlated inversely but weakly with dietary alpha-tocopherol (r = -0.24, p less than 0.05).”

“This finding suggests either that there is a small depletion-resistant subcellular alpha-tocopherol pool which regulates PGF2 alpha production or that alpha-tocopherol alters PGF2 alpha production in vivo by an indirect mechanism.”

“The possibility that alpha-tocopherol may inhibit the formation of endoperoxide intermediates of PGE2 and PGF2alpha biosynthesis and subsequent induction of platelet aggregation is discussed.”

“These data suggest that in vitro alpha-tocopherol inhibits the endogenous conversion of arachidonic acid into PGE2 and PGF2alpha.”