Possible Interaction: Dinoprost and Vitamin C

“The results of both animal and human studies indicate that an inverse relationship exists between the levels of AA and the amount of PGF2 alpha synthesized and/or released in the body tissues.”

“This finding suggests that PGF2 alpha depletes the pig corpus luteum of vitamin C by inducing secretion of the vitamin into the bloodstream.”

“Luteal vitamin C concentration and steady-state concentrations of mRNA for 3beta-hydroxysteroid dehydrogenase and for FP receptor were decreased by 4 h in both Day 4 and 11 CL treated with PGF2alpha (p < 0.05).”

“Also novel was the … cell secretion of ascorbic acid was rapidly … by PGF2 alpha (IC50 about 5 nM), an effect mimicked by LH, H2O2, generators of reactive oxygen, calcium ionophore, and cytochalasin … of ascorbic acid was energy-dependent, as secretion was blocked by a mitochondrial uncoupler and lowered temperature.”

“Also, the time course for half-maximal depletion of ascorbic acid in vivo in response to PGF2 alpha was extremely rapid (2-3 min) compared to that known for LH (60 min).”

“The ability of PGF2 alpha to inhibit ascorbate transport and to stimulate secretion implicates these processes as the basis for the rapid depletion of ascorbic acid in the CL.”

“Acute treatment with PGF2 alpha produced a transient decrease in luteal vitamin C levels coincident with transient lipid peroxidation and a sustained fall in serum progesterone levels.”

“The opposite effect was observed when PGF2 alpha was added in presence of L-ascorbic acid : a depression of tracheal smooth muscle contraction occurred.”