Possible Interaction: Dinoprost and Tretinoin

“These results strongly suggest that RA inhibits PGE2 synthesis induced by PGF2 alpha in osteoblast-like cells and the inhibitory effect is exerted at the point prior to the activation of phospholipase A2.”

“… RA , which by … by PGF2 alpha in a dose-dependent manner in the range between 1 nM and 0.1 microM. This effect of RA was dependent on … inhibited the amplification of PGF2 alpha-induced PGE2 synthesis by 12-O-tetradecanoylphorbol-13-acetate, known to be a PKC activator.”

“ Retinoic acid … PGF2alpha or PGE1 in a dose-dependent manner in the range between 0.1 and 10 nM. Retinoic acid also suppressed the IL-6 …, an activator of protein kinase C. The IL-6 synthesis induced by cholera toxin, forskolin or dibutyryl cAMP was inhibited by retinoic acid.”

“These results strongly suggest that RA suppresses the phospholipase D activated by PGF2 alpha in osteoblast-like cells and that the effect of RA is exerted at the point between PGF2 alpha receptor and G-protein.”

“… RA … PGF2 alpha (10 microM) in a dose-dependent manner in the range between 1 nM and 0.1 microM. This inhibitory effect of RA was … little effect on the choline formation induced by NaF, a G-protein activator, or 12-O-tetradecanoylphorbol-13-acetate, an activator of PKC.”

“ Retinoic acid stimulated the synthesis and release of prostaglandin F2 alpha and production of I-activity in M1 cells.”

“ Abstract Retinoic acid at concentrations of 10−8–10−6M increases the initiation of DNA synthesis stimulated by prostaglandin F2α (PGF2α), alone or with insulin, in confluent resting Swiss mouse 3T3 cells.”