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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprost
supplement:
Progestins
Research Papers that Mention the Interaction
“A pilot experiment was designed to test the hypothesis that administration of PGF2α before progestin treatment would allow for a reduced duration of progestin treatment in a long-term progestin-based estrus synchronization protocol.”
The 9-day CIDR-PG protocol: Incorporation of PGF2α pretreatment into a long-term progestin-based estrus synchronization protocol for postpartum beef cows.“At 8–45 h PGF2α reduced the percent progesterone out of total progestins , and at 45 h 20α-HSD mRNA was doubled.”
“In prolactin-treated cells, PGF2α reduced steroidogenesis after 4–45 h, and at 45 h total progestins and P450scc mRNA were reduced by 45%.”
“The embryo mortality associated with luteolytic doses of PGF2alpha in cows receiving replacement therapy with progestogen probably involves compounds that either act systemically or are transported via the uterine lumen to the uterine horn contralateral to the regressing CL.”
“ PGF2alpha injected on day 17 resulted in a precipitous decline in plasma progestin concentration and onset of estrus by 110 and 90 hours in gilts 1 and 2, respectively.”
“the addition of PGF2alpha under in vitro conditions strikingly decreased the production of these progestins.”
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