Possible Interaction: Dinoprost and Polyunsaturated Fatty Acids

“ D‐PUFA treatment markedly decreased cortex and hippocampus F2‐isoprostanes by approximately 55% and prostaglandin F2α by 20–25% as compared to H‐PUFA treatment.”

“In both settings, we found that after supplementing with n-3 PUFA , PGE2 and PGF2 alpha were significantly reduced.”

“In a previous publication we reported that PUFAs of the n-6 and n-3 series caused significant inhibition of synthesis of both PGE2 (28.4-92.8%) and PGF2 alpha (24.4-84.0%) in the oral squamous carcinoma cell line SCC-25.”

“Both n-3 polyunsaturated fatty acids PUFAs ) and conjugated linoleic acid (CLA) can alter biosynthesis of prostaglandins E(2) (PGE(2)) and prostaglandin F2α (PGF(2α)), which have critical roles in animal reproduction.”

“ Polyunsaturated fatty acids such as linoleic, linolenic, … docosahexaenoic acids may inhibit prostaglandin F2alpha synthesis through mechanisms such as decreased availability of its precursor arachidonic acid, an increased competition by these fatty … with arachidonic acid for binding to prostaglandin H synthase, and inhibition of prostaglandin H synthase synthesis and activity.”

“Norepinephrine stimulated prostaglandin E2 and F2alpha production was significantly (P less than 0.01) increased with greater polyunsaturation of fat, but not by increased fat calories.”