Possible Interaction: Dinoprost and Masoprocol

“Antioxidants such as butylated hydroxytoluene (BHT), nordihydroguaiaretic acid (NDGA), or dimethylurea exhibited an only minimal inhibitory effect on 8‐epi‐PGF2α synthesis.”

“In contrast, pretreatment with NDGA and ETYA inhibited PGF2 alpha-induced PtdEt accumulation.”

“The enhanced response to PGF2 alpha in diabetic blood vessels was significantly inhibited by nordihydroguaiaretic acid (NDGA) (0.03 mM) and phenidone (0.05 mM), lipoxygenase inhibitors, cycloheximide (1 mg/kg, i.v.),”

“Intrauterine administration of nordihydroguaiaretic acid (NDGA) will maintain luteal function in sheep and also suppress the release of both oxytocin and prostaglandin F2 alpha (PGF2 alpha) suggesting that 5-lipoxygenase products of arachidonic acid may be involved in ovine luteolysis.”

“These NDGA concentrations also inhibited vasomotor responses to KCl, serotonin and PGF2 alpha suggesting nonspecificity.”

“The cyclooxygenase inhibitor ibuprofen eliminated PGF2 alpha production, while the lipoxygenase inhibitors baicalein and NDGA reduced PGF2 alpha accumulation.”

“The lipoxygenase inhibitor NDGA also reduced the accumulation of PGE2 and PGF2 alpha.”

“Ovarian tissue levels of prostaglandins after 7 h of perfusion with LH + NDGA or with LH alone showed that, in five of the six ovaries perfused in this group, the tissue levels of PGE2, 6-keto-PGF1 alpha and PGF2 alpha were higher in the presence of NDGA.”

“BW755c and nordihydro‐guaiaretic acid do not affect PGE2 formation but enhance PGF2a production by 112% and 152%, respectively.”

“The intrauterine infusion of NDGA for 24 h inhibited the release of PGE2, PGF2 alpha , LTC4 and LTB4 as compared to those released by the vehicle-infused horns.”