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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprost
supplement:
Linolenic Acid
Research Papers that Mention the Interaction
“Polyunsaturated fatty acids … as linoleic, linolenic , eicosapentaenoic and docosahexaenoic … may inhibit prostaglandin F2alpha synthesis through mechanisms such as decreased availability of its precursor arachidonic acid, an increased competition by these fatty … with arachidonic acid for binding to prostaglandin H synthase, and inhibition of prostaglandin H synthase synthesis and activity.”
Effects of dietary fatty acids on reproduction in ruminants.“Since linolenic acid inhibits the conversion of linoleic acid to arachidonic acid (PGE2, PGF2 alpha , and thromboxane A2 precursor), rats receiving more linolenic acid are expected to have less arachidonic acid and thus less PG's synthesized from arachidonic acid than those receiving linoleic acid alone.”
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