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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dinoprost
supplement:
Linoleic Acid
Research Papers that Mention the Interaction
“Both n-3 polyunsaturated fatty acids (PUFAs) and conjugated linoleic acid (CLA) can alter biosynthesis of prostaglandins E(2) (PGE(2)) and prostaglandin F2α (PGF(2α)), which have critical roles in animal reproduction.”
A diet rich in n-3 polyunsaturated fatty acids reduced prostaglandin biosynthesis, ovulation rate, and litter size in mice.“Polyunsaturated fatty … such as linoleic , linolenic, eicosapentaenoic and … acids may inhibit prostaglandin F2alpha synthesis through mechanisms such as decreased availability of its precursor arachidonic acid, an increased competition by these fatty … with arachidonic acid for binding to prostaglandin H synthase, and inhibition of prostaglandin H synthase synthesis and activity.”
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