Possible Interaction: Dinoprost and Glucose

“Changes in the plasma concentration of glucose in the treatment group were significantly (P < 0.05) higher than those of the control groups during the period between 0 and 72 h after PGF2α administration.”

“For the samples taken at 6-h intervals after PGF2α administration, the concentrations of glucose showed clear daily fluctuations in both groups.”

“The mean plasma concentrations of NEFA, cortisol and glucose showed rises after PGF2α.”

“… PGF2alpha … basal glucose uptake in a time- and dose-dependent manner, reaching maximum at approximately 8 h. The long-term effect of PGF2alpha on glucose transport … not altered, immunoblot and Northern blot analyses revealed that both GLUT1 protein and mRNA levels were increased by exposure of cells to PGF2alpha.”

“We conclude that PG F2 alpha increases glucose and lactate production in the perfused rat liver and decreases portal flow bile secretion.”

“In perfused rat livers, infusion of prostaglandin F2 alpha (PGF2 alpha) or noradrenaline increased glucose and lactate output and reduced flow.”

“4) Prostaglandin F2 alpha increased glucose and lactate release and decreased perfusate flow.”

“In uterine strips from spayed non-estrogenized rats incubated with indomethacin, only PGE2 (10(-7) and 10(-6) M) incremented the formation … PGE1 and PGF2 alpha were devoid of action, whereas in uteri from ovariectomized-estrogenized animals also incubated with indomethacin, PGE1, PGE2 and PGF2 alpha … glucose , as … indomethacin.”

“The injection of PGF2 alpha into the ventricle resulted in the increase of not only glucose , but also glucagon, epinephrine, and norephinephrine in the hepatic venous plasma.”

“In the presence … 16.7 mM glucose , in response to 1.4 × 10−6 … PGE2 and 2.8 × 10−7 M PGF2α , the release of glucagon was blunted and that of insulin unchanged as compared with the secretory responses seen in the presence of 5.6 mM D-glucose.”