Possible Interaction: Dinoprost and Calcium Supplement

“ PGF2alpha increased the calcium sensitivity during both the contractile (rising) and relaxation (falling) phases of a contraction.”

“High concentrations (to 10(-6) mol/l) of PGF2 alpha were associated with a dose-dependent increase of calcium (45Ca) efflux, whereas at concentrations lower than 10(-8) mol/l there was little or no 45Ca efflux.”

“ PGF2 alpha may promote trans-membrane influx of calcium , as well as release calcium from seemingly superficially located cellular stores.”

“The seminal parameters that were significant predictors of seminal PGF2 alpha included: Ca++ concentration (P less than 0.001), Zn++ concentration (P less than 0.01), and percentage of tapered sperm (P less than 0.05).”

“It is suggested that PGF2alpha induces contraction both by enhancing the transmembrane flow of calcium , and by facilitating release of calcium from intracellular stores.”

“Therefore, … PGF2alpha … calcium signal of greater magnitude in mature than in developing CL involve 1) greater PLCbeta activity with enhanced generation of IP3, 2) an enhanced Ca2+ … to a decrease in SRI expression, and 3) a reduction in calcium reuptake to the ER due to lower expression of ATP2A2.”

“In a second experiment, the response to oxytocin was increased (P < 0.05) by 3 h (but … h) following progesterone removal, with a further increase by 16 h. The ability of 1 μM prostaglandin F2alpha (PGF2alpha) to increase … concentrations of calcium was also decreased (P < ….05) by progesterone treatment.”

“Thus, depending on the time window, prostaglandins, specially PGF2alpha , may enhance or diminish the propagation of Ca2+ signals.”

“Co‐incubation with prostaglandins E1 and E2 (PGE1, PGE2) (10 μM) but not prostaglandin F2α (PGF2α) (10 μM) significantly inhibited calcium‐ , GTP‐γ‐S and mastoparan‐evoked secretion by 30 – 50%.”

“During oviposition, PGF2 alpha and vasotocin stimulate powerful uterine contractions [32] in the presence of calcium.”