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Last Updated: 3 years ago
drug:
Dimethyl Sulfoxide
supplement:
Methionine
Research Papers that Mention the Interaction
“Our study also demonstrated that DMSO inhibits in vivo methionine sulfoxide reduction in yeast and mammalian cells. [”
Inhibition of methionine sulfoxide reduction by dimethyl sulfoxide.“Notably, DMSO inhibited methionine sulfoxide reductase activity, induced heme oxygenase-1 (ho-1) mRNA and enhanced oxidant-induced cell death, which indicated that DMSO intensified oxidative stress.”
“… L-Met at low concentrations (…) were abolished by dimethyl sulfoxide (DMSO), a competitive inhibitor of MsrA function, suggesting that these effects may involve the participation of MsrA. Overexpression of MsrA … CHO cells protected mitochondria from H(2)O(2)-induced downtrend of membrane potential and production of mitochondrial superoxide.”
Protection of L-methionine against H₂O₂-induced oxidative damage in mitochondria.“The in vitro permeation studies found that M was superior to G and C and that adding DMSO to M increased the permeation rate.”
“ Dimethylsulfoxide markedly stimulated the activities of the two beta-forms at low methionine concentrations.”
“If added 24 h before DMSO , the inhibitory effects of MPA and dexamethasone increased to 65 % and 95 %, respectively, whereas indomethacin ( 10−5 M ) caused only a 30 % inhibition and the other drugs were inactive.”
“MPA at low doses (10−6 - 10−7 M) induced 10–15 % cells to differentiate, whereas high doses (10−4 - 10−5 M ) caused a 30 % inhibition of dimethylsulfoxide (DMSO)-induced differentiation.”
“The Km for methionine was 10.6 microM. In the presence of 10% dimethyl sulfoxide , the enzyme activity was slightly inhibited and dithiothreitol was not required for maximum activity.”
“ Summary Dimethylsulfoxide at a concentration of 10% stimulates one isozyme of rat liver methionine adenosyltransferase 50–70 fold when assayed at low (25 μM) methionine.”
“Our previous study showed that DMSO can competitively inhibit methionine sulfoxide reduction ability of yeast and mammalian MsrA in both in vitro and in vivo, and also act as a non-competitive inhibitor for mammalian MsrB2, specific for the reduction of methionine-R-sulfoxide, with lower inhibition effects.”
Dimethyl sulfoxide elevates hydrogen peroxide-mediated cell death in Saccharomyces cerevisiae by inhibiting the antioxidant function of methionine sulfoxide reductase A.“Addition of 10−1 M DMSO typically decreased damage yields by a factor of less than 0.5.”
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