Possible Interaction: Dimethyl Sulfoxide and Glutathione

“In case of cells treated either with BC or L delivered through THF and AST in DMSO decreased the glutathione and increased the malondialdehyde levels.”

“Total Glutathione concentrations increased in blastocyst stage in DMSO group.”

“ GSH levels increased significantly in T-0 and T-3 time-points in DMSO pretreated rats compared with G-1 rats.”

“The DMSO at 0.1% increased the lipid peroxidation, GSH concentration, apoptosis and DNA damage.”

“ DMSO pretreatment also attenuated the initial decline in hepatic glutathione levels.”

“N-Acetyl-L-cysteine (NAC) also reduced the increase in glutathione to some extent, whereas both peroxynitrite scavenger ebselen and hydroxyl radical scavenger DMSO inhibited the increase in glutathione in a dose-dependent manner and complete inhibition was observed.”

“We also show that DMSO can inhibit in vivo production of glutathione conjugates of paracetamol.”

“The APAP-induced depletion of liver glutathione was prevented in mice pretreated with DMSO , although DMSO alone had no effect on liver glutathione levels.”

“ Hepatic glutathione depletion in mice amounting to 94% after paracetamol (0·5 g kg−1, orally) and to 60% after bromobenzene (0·25 ml kg−1, orally) was dose‐dependently reduced by the simultaneous administration of DMSO (0·25–1·0 g kg−1, i.p.).”

“ Dimethyl sulfoxide was shown to react with glutathione as well as eye lens proteins to yield dimethyl sulfide.”